Ventricular repolarization measures for arrhythmic risk stratification

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Novel conduction-repolarization indices for the stratification of arrhythmic risk

Sudden cardiac death (SCD) affects approximately 800,000 individuals per annum globally. It is most frequently due to cardiac tachy-arrhythmias, which include mono-morphic or polymorphic ventricular tachycardia (VT), torsade de pointes and ventricular fibrillation (VF). Risk stratification for SCD remains a challenging problem in clinical practice. Patients with structural heart disease or card...

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Dispersion of ventricular depolarization-repolarization: a noninvasive marker for risk stratification in arrhythmogenic right ventricular cardiomyopathy.

BACKGROUND We retrospectively investigated the value of clinical and ECG findings as well as QT-QRS dispersion in predicting the risk of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). METHODS AND RESULTS Duration and interlead variability of the QT interval and QRS complex were measured manually from standard ECGs in 20 sudden death victims with ARVC dia...

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Risk stratification for arrhythmic sudden cardiac death: identifying the roadblocks.

Athough it is difficult to determine the precise number, the range for the number of sudden cardiac deaths (SCDs) per year in the United States alone has been reported from 184 000 to 462 000,1 with estimates that 50% to 70% are due to tachyarrhythmic mechanisms. Regardless of where within this range the true number lies, this represents a large epidemiological problem that warrants serious att...

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Exploiting rate-related hysteresis in repolarization alternans to improve risk stratification for ventricular tachycardia.

OBJECTIVES We sought to study the effect of heart rate acceleration and deceleration on the ability of repolarization alternans (RPA) to stratify ventricular tachycardia (VT) risk. BACKGROUND Heart rate fluctuations alter arrhythmic propensity, yet it is unclear whether fluctuations, as well as absolute rate, dynamically increase VT risk. We hypothesized that repolarization heterogeneity refl...

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ژورنال

عنوان ژورنال: World Journal of Cardiology

سال: 2016

ISSN: 1949-8462

DOI: 10.4330/wjc.v8.i1.57